Efferocytosis Intracellular HMGB1 Negatively Regulates
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منابع مشابه
MFG-E8 and HMGB1 are involved in the mechanism underlying alcohol-induced impairment of macrophage efferocytosis.
Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility group box 1 (HMGB1). Alcohol abuse causes injury and inflammation in multiple tissues. It alters efferocytosis, but precise molecular mechanisms for this effect remain largely unknown. Her...
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Friggeri A, Yang Y, Banerjee S, Park Y, Liu G, Abraham E. HMGB1 inhibits macrophage activity in efferocytosis through binding to the v 3-integrin. Am J Physiol Cell Physiol 299: C1267–C1276, 2010. First published September 8, 2010; doi:10.1152/ajpcell.00152.2010.— Phagocytosis of apoptotic cells is critical to resolution of inflammation. High mobility group box 1 protein (HMGB1), a mediator of ...
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